Saturday, October 17, 2026

Preprints

• Sat, Oct 17Foundation modelVirtual cell

  Spatial benchmark tests how models predict individual RNA movements after cell perturbations

  A new benchmark named SubcellPert compiles 14 imaging datasets spanning 13.88 million cells and 3.65 billion RNA molecules to evaluate how computational models predict subcellular spatial reorganization after cellular interventions.

  Jinghao Wang, Hanqun Cao, Xilin Dang, and 5 othersJinghao Wang, Hanqun Cao, Xilin Dang, Tianhui Zhou, Yiyang Zhao, Chang-Yu Hsieh, Chunbin Gu, Pheng Ann Heng fewer authors

  Chinese University of Hong Kong; University of Hong Kong; Duke; Zhejiang

  bioRxiv
• Sat, Oct 17AI drug discoveryFoundation model

  Graph neural network pinpoints small-molecule docking pockets on RNA

  LigRNA combines an RNA language model, structural surface features, and graph attention networks to predict where small-molecule drugs bind to RNA targets.

  Xin Wang, Heqin Zhu, Hao Li, and 7 othersXin Wang, Heqin Zhu, Hao Li, Ao Chang, Feng Zhang, Haobin Chen, Chenxi Wang, Ke Chen, S Kevin Zhou, Peng Xiong fewer authors

  University of Science and Technology of China; Chinese University of Hong Kong; University of Hong Kong

  bioRxiv