Diasome readies Phase 3 plans for liver-targeted insulin in type 1 diabetes
Diasome is advancing its hepatocyte-directed vesicle formulation of insulin lispro into Phase 3 trials for adults with type 1 diabetes.
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Preprints
Hierarchical distribution matching separates healthy and diseased tissue microenvironments
A computational framework named Harmonics maps shared and condition-specific cellular niches across spatial omics platforms using hierarchical distribution matching.
Experimental distance clues steer AlphaFold-Multimer to accurate protein assemblies
Distance-AF Multimer steers AlphaFold-Multimer docking models using measured distances between amino-acid pairs, correcting assemblies where deep-learning algorithms miss the mark.
Mass spectrometry limits, not chemical reactivity, cap cysteine drug screens
Explainable machine learning models trained on tryptic peptides revealed that mass-spectrometry detectability and underlying protein abundance, rather than local structural reactivity, govern cysteine coverage in iodoacetamide-desthiobiotin chemoproteomics.
Budget-aware AI agent system trims compute waste when fine-tuning protein models
Researchers built CAPO, an automated multi-agent framework designed to test training feasibility on hardware and reject unaffordable runs before adapting large protein models to specialized lab assays.
Neural network traces cell lineage and tumor spread directly in spatial tissue slices
Researchers developed StarTrak, a deep-learning method that calls somatic mutations directly from spatial genomics data to reconstruct lineage trees and cell migration across intact tissue sections.