FDA approves AbbVie's oral Parkinson's drug tavapadon
The FDA cleared tavapadon, marketed as Juvmo, as a once-daily oral selective D1/D5 dopamine receptor agonist for use as a monotherapy or alongside levodopa.
News
BioNTech to close three German sites, cutting 1,800 jobs after sale talks fail
BioNTech will shut down three facilities across Germany after negotiations to find outside buyers for the locations collapsed.
Fierce Pharma, also reported by ReutersEndpoints News (subscription required)
Preprints
Targeted fine-tuning teaches protein folding models how drug binding changes shape
Fine-tuning the open-source co-folding model Boltz-1 on ten proprietary X-ray structures of Werner helicase enabled it to predict both an unseen allosteric binding pocket and the large inactive conformational shift induced by small molecules.
Single-cell foundation models show uneven gains across aging benchmarks
A benchmark evaluating ten general-purpose single-cell foundation models, three aging-specific models, and classical baselines across 2.5 million cells found that model utility depends heavily on the specific biological task.
Genome AI model uncovers hidden genes viruses use to hijack host cells
CheckAMG combines standard functional annotation with a fine-tuned genomic language model to find auxiliary viral genes, which phages and other viruses use to rewire host metabolism, physiology, and regulation.
Single-nucleus multi-omic atlas maps gene switches across 21 human tissues
Researchers generated an atlas of 459,856 single-nucleus gene expression and chromatin accessibility profiles across 21 adult human tissues from four donors, pinpointing over one million candidate regulatory elements.