The front page of AI-driven biology
Thursday, October 15, 2026Thu, Oct 15
Updated 6:32 PM PT
Kyverna Therapeutics reported that a single dose of its autologous cell therapy mivocabtagene autoleucel (miv-cel) maintained a 49% median improvement in mobility at 12 months in a 26-patient registrational trial for stiff person syndrome.
Anthropic announced that its wet biology lab discovered an enzyme system hidden in bacteriophage DNA that functions similarly to CRISPR by cutting, copying, and pasting genetic material.
An FDA advisory committee voted 7 to 2, with one abstention, that the benefits of Grail's Galleri multi-cancer early detection blood test outweigh its risks for indicated patients.
Genialis and Inventia Life Science have partnered to match bioprinted 3D pancreatic cancer models with specific clinical patient subtypes.
Chemists at New York University created an open-source machine learning model called Tautomer-Predictor to determine the most stable structural forms of drug candidates by predicting hydrogen atom positions.
The partnered monthly antisense injection sefaxersen significantly lowered protein in the urine of patients with IgA nephropathy at an interim check, the companies announced.
The U.S. Department of War has awarded venture creator Flagship Pioneering a five-year, $47 million contract to build medical countermeasures against emerging biological and chemical threats.
The funding supports clinical expansion for two lead oral small molecules, including mid-stage trials of ENV-294 in atopic dermatitis and asthma after early data showed an 85% symptom reduction by Day 42.
The German drugmaker added over $250 million in potential upfront, license, and milestone payments to tap Variant's machine-learning platform for cardiovascular drug targets.
S32 led the oversubscribed Series C round for Basecamp Research, which uses its EDEN biological foundation model to design in vivo cell therapies that reprogram patient cells inside the body.
Immunovant has halted development of its anti-FcRn antibody IMVT-1402 in cutaneous lupus erythematosus after the drug failed a 57-patient Phase 2 trial against placebo.
A new mathematical framework recasts spectral information theory into an interpretable metric called Leff, which calculates the effective number of fully independent positions that capture sequence variation.
Researchers applied the protein design algorithms PROSS and FuncLib to redesign human T cell receptor constant domains, creating a variant called structurally enhanced TCR that boosts surface expression and prevents faulty pairing.
Scientists built iBrainMap, an open-source computational framework based on knowledge-guided graph neural networks to model personalized gene regulatory networks from single-nucleus RNA sequencing data.
Investigators built predictive machine learning models to infer cell-type-specific gene expression from single-nucleus data generated in the multi-ancestry PsychAD cohort.
Researchers guided large language models to suggest specific chemical modifications that make computationally generated molecules easier to synthesize in the laboratory.
A combined imaging workflow links Xenium spatial transcriptomics with iterative indirect immunofluorescence imaging on the same section of preserved human brain tissue.
Researchers mapped single-cell gene expression and paired T- and B-cell receptor sequences from the blood of 249 individuals with inflammatory bowel disease or healthy controls.
Researchers used structural modeling from AlphaFold3 to engineer dual-excitation ratiometric biosensors that track neuropeptides in live animals without interference from blood flow, tissue movement, or pH shifts.
Target-adaptive Rescue-Explore-eXploit, or T-REX, uses large language model agents to orchestrate multiple generative models and structure-evaluation tools during protein binder design campaigns.
Researchers introduced Minerva, an alignment-free framework that uses a genome language model to predict RNA base-pairing, protein contacts, and repeat sequences as two-dimensional interaction maps.