Novo drops Nordisk in corporate rebrand as weight-loss rivalry intensifies
The Danish drugmaker is rebranding simply as Novo alongside a corporate culture overhaul, following a 15% stock decline in 2026.
News
FDA approves Scholar Rock's apitegromab for spinal muscular atrophy
Scholar Rock has secured FDA approval for apitegromab, an injectable monoclonal antibody targeting muscle loss in spinal muscular atrophy.
GE HealthCare weighs $1B purchase of radiopharmaceutical maker Sofie Biosciences
GE HealthCare is considering a buyout of cancer-imaging chemical developer Sofie Biosciences for up to $1 billion, according to a report by the Financial Times.
Novartis faces investor backlash after $12B muscle-drug acquisition fails Phase 3
Novartis lost roughly $30 billion in market value after delpacibart etedesiran failed to beat placebo on hand opening time at 54 weeks in the Phase 3 HARBOR trial for myotonic dystrophy type 1. The drug is an antibody-oligonucleotide conjugate, designed to deliver siRNA to muscle cells via the transferrin receptor 1, which Novartis acquired in its $12 billion buyout of Avidity Partners.
Publications
Multimodal AI guides lung cancer immunotherapy decisions in large clinical study
Investigators evaluated machine learning and deep learning decision-support models across 2,396 patients with non-small cell lung cancer treated with immunotherapy in the I3LUNG trial.
Preprints
Generative model designs proteins directly in all-atom 3D space
Computational biologists introduced PANDA, an end-to-end generative architecture that designs proteins by denoising atomic coordinates in unified 3D space and reading sequence directly from atomic positions.
Language model filters noise from genome-wide poxvirus infection screen
Researchers introduced ICARus, a computational framework that uses protein language model predictions to reduce off-target noise in RNA interference functional screens.
Expanded RNA-binding database adds 3D pocket shapes and affinity data
Researchers released HARIBOSS++, an updated structural database and web platform cataloging small molecules that bind RNA.
A subset of HIV elite controllers shows non-infected blood protein levels
Profiling 384 plasma proteins across 62 untreated HIV elite controllers revealed that a distinct subset of 9 individuals has inflammatory profiles matching people without HIV.