Novo Nordisk reported that 40% of pediatric participants receiving the GLP-1 receptor agonist Wegovy (semaglutide) were no longer classified as having obesity in a Phase 3 pediatric trial.
Amgen's bispecific T-cell engager Imdelltra (tarlatamab), which targets DLL3 to direct immune cells against tumors, demonstrated a statistically significant improvement in overall survival in a first-line small-cell lung cancer trial.
The computational tool IRIS uses transfer learning to infer in vivo signaling dynamics and cellular histories from single-cell gene expression atlases.
Nicholas T Hutchins, Miram Meziane, Claire Lu, and 3 othersNicholas T Hutchins, Miram Meziane, Claire Lu, Maisam Mitalipova, David S Fischer, Pulin Li fewer authorsMIT; Whitehead Institute; Harvard; and 2 othersMIT; Whitehead Institute; Harvard; Broad Institute; University of Vienna fewer institutions
MemBrain v2 provides an integrated software suite for segmenting cell membranes, picking membrane-bound proteins, and computing spatial statistics in cryo-electron tomography.
Lorenz Lamm, Simon Zufferey, Hanyi Zhang, and 12 othersLorenz Lamm, Simon Zufferey, Hanyi Zhang, Ricardo D Righetto, Florent Waltz, Wojciech Wietrzynski, Kevin A Yamauchi, Alister Burt, Ye Liu, Antonio Martinez-Sanchez, Sebastian Ziegler, Fabian Isensee, Julia A Schnabel, Benjamin D Engel, Tingying Peng fewer authorsHelmholtz; University of Basel; Technical University of Munich; and 8 othersHelmholtz; University of Basel; Technical University of Munich; ETH Zurich; Swiss Institute of Bioinformatics; MRC Laboratory of Molecular Biology; Genentech; University of Murcia; Heidelberg; King's College London; Munich Center for Machine Learning fewer institutions
PRIS is a structure-based deep learning framework designed to model protein-RNA complexes and screen large RNA candidate libraries for therapeutic development.
Researchers combined embeddings from the genomic language model Evo2 with evolutionary ortholog data and protein interaction networks to predict which genes are essential for fungal survival.
scFLAME is a generative probabilistic model that performs dimensionality reduction, batch correction, cell clustering, and marker-gene identification in a single step from single-cell RNA sequencing counts.
Jackie Rao, Muntadher Jihad, Giulia Biffi, Paul D.W. Kirk
CellART is an open computational method that segments individual cells and identifies their cell types directly from high-resolution spatial transcriptomics data, which measures gene activity across tissue slices.
Yuheng Chen, Yuyao Liu, Zhiwei Wang, and 7 othersYuheng Chen, Yuyao Liu, Zhiwei Wang, Yeqin Zeng, Zitong Chao, Peiqi Jiang, Hao Chen, Jiguang Wang, Jiashun Xiao, Can Yang fewer authors
Hong Kong University of Science and Technology; Sun Yat-sen